Tuberculosis and diabetes
| Autor: | Doorn, C.L.R. van |
|---|---|
| Přispěvatelé: | Ottenhoff, T.H.M., Vianello, E., Geluk, A., Hoeben, R.C., Spaink, H.P., Houben, E.N.G., Leiden University |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | None |
| Popis: | In this thesis we describe our work regarding the identification of novel biomarkers, host targets and candidate pharmacological compounds for the development of therapies against various intracellular bacterial infections, focusing primarily on the interplaybetween tuberculosis and diabetes mellitus. We conducted two longitudinal cohort studies in South Africa and Indonesia, and we applied unbiased and selective transcriptomic approaches to identify novel biomarker profiles in tuberculosis patients with concomitant diabetes or hyperglycaemia. Further, we performed experiments with standardized in vitro cellular infection models for drug discovery. We identified potential host targets during Mycobacterium tuberculosis infections and we describe the role of central metabolic pathways bacterial infections in human macrophages. |
| Databáze: | OpenAIRE |
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