Moving upstream : evaluating adverse upstream end points for improved risk assessment and decision-making

Autor: Woodruff, Tracey J., Zeise, Lauren, Axelrad, Daniel A, Guyton, Kathryn Z, Janssen, Sarah, Miller, Mark, Miller, Gregory G., Schwartz, Jackie, Alexeeff, George, Anderson, Henry, Birnbaum, Linda, Bois, Frédéric Y., Cogliano, Vincent James, Crofton, Kevin, Euling, Susan Y., Foster, Paul M. D., Germolec, Dori R., Gray, Earl, Hattis, Dale B., Kyle, Amy D., Luebke, Robert W., Luster, Michael I., Portier, Chris, Rice, Deborah C., Solomon, Gina, Vandenberg, John, Zoeller, R. Thomas
Přispěvatelé: Department of Obsetrics and Gynecology / Program on Reproductive Health and Environment, University of California, Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Office of Policy / Economics and Innovation, US Environmental Protection Agency (EPA), National Center for Environmental Assessment, Department of Medecine, National Resource Defence Council, Pediatric Environmental Health Specialty Unit, Wisconsin Division of Public Health, EPA National Health and Environmental Effects Research Laboratory, Institut National de l'Environnement Industriel et des Risques (INERIS), Centre internationale de recherche sur le cancer, Departement of Health and Human Services, National Institute of Environmental Health Sciences [Durham] (NIEHS-NIH), National Institutes of Health [Bethesda] (NIH)-National Institutes of Health [Bethesda] (NIH), George Perkins Marsh Institute, Clark University, School of Public Health, National Institute for Occupational Safety and Health, Environmental and Occupational Health Program, Maine Center for Disease Control and Prevention, Department of Biology, University of Massachusetts System (UMASS)
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Zdroj: Environmental Health Perspectives
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2008, 116 (11), pp.1568-1575. ⟨10.1289/ehp.11516⟩
ISSN: 0091-6765
1552-9924
DOI: 10.1289/ehp.11516⟩
Popis: International audience; BACKGROUND: Assessing adverse effects from environmental chemical exposure is integral to public health policies. Toxicology assays identifying early biological changes from chemical exposure are increasing our ability to evaluate links, between early biological disturbances and subsequent overt downstream effects. A workshop was held to consider how the resulting data inform consideration of an "adverse effect" in the context of hazard identification and risk assessment. OBJECTIVES: Our objective here is to review what is known about the relationships between chemical exposure, early biological effects (Upstream events), and later overt effects (downstream events) through three case studies (thyroid hormone disruption, antiandrogen effects, immune system disruption) and to consider how to evaluate hazard and risk when early biological effect data are available. DISCUSSION: Each case study presents data on the toxicity pathways linking early biological perturbations with downstream overt effects. Case studies also emphasize several factors that can influence risk of overt disease as a result from early biological perturbations, including background chemical exposures, underlying individual biological processes, and disease susceptibility. Certain effects resulting from exposure during periods of sensitivity may, be irreversible. A chemical can act through multiple modes of action, resulting in similar or different overt effects. CONCLUSIONS: For certain classes of early perturbations, Sufficient information oil the disease process is known, so hazard and quantitative risk assessment can proceed using information on upstream biological perturbations. Upstream data will Support improved approaches for considering developmental stage, background exposures, disease status, and other factors important to assessing hazard and risk for the whole population
Databáze: OpenAIRE
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