| Autor: |
Apte, Shashank S., Weber, Nikolaus, Mangold, Helmut K. |
| Jazyk: |
angličtina |
| Předmět: |
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| Zdroj: |
FEBS Letters. (1-2):104-106 |
| ISSN: |
0014-5793 |
| DOI: |
10.1016/0014-5793(90)80894-O |
| Popis: |
Biotransformation of rac-1(3)-O-hexadecylglycerol by photomixotrophic rape (Brassica napus) cells in suspension culture leads to 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphocholines and small proportions of other ether lipids, e.g. 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamines. Reaction of the hexadecylacyl-glycerophosphocholines with ethanolamine in the presence of phospholipase D from Streptomyces chromofuscus yields additional hexadecylacylglycerophosphoethanolamines. Partial hydrolysis of the combined hexadecylacylglycerophosphoethanolamines followed by reacylation of the resulting lyso compound with palmitic anhydride gives 1-O-hexadecyl-2-palmitoyl-sn-glycero-3-phospho-(N-palmitoyl) ethanolamine, a nontoxic ether glycerophospholipid with antitumor activity. The corresponding 1-O-tetradecyl,1-O-octadecyl, and 1-O-[(Z)-9'-octadecenyl] derivatives are prepared similarly. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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