| Autor: |
Norquay, G., Collier, G.J., Rodgers, O.I., Gill, A.B., Screaton, N.J., Wild, J. |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| ISSN: |
0007-1285 |
| Popis: |
Objectives\ud \ud Design and build a portable xenon-129 (129Xe) hyperpolariser for clinically accessible 129Xe lung MRI.\ud \ud \ud \ud Methods\ud \ud The polariser system consists of six main functional components: (i) a laser diode array and optics; (ii) a B0 coil assembly; (iii) an oven containing an optical cell; (iv) NMR and optical spectrometers; (v) a gas-handling manifold; and (vi) a cryostat within a permanent magnet. All components run without external utilities such as compressed air or three-phase electricity, and require just three mains sockets for operation. The system can be manually transported in a lightweight van and rapidly installed on a small estates footprint in a hospital setting.\ud \ud \ud \ud Results\ud \ud The polariser routinely provides polarised 129Xe for routine clinical lung MRI. To test the concept of portability and rapid deployment, it was transported 200 km, installed at a hospital with no previous experience with the technology and 129Xe MR images of a diagnostic quality were acquired the day after system transport and installation.\ud \ud \ud \ud Conclusion\ud \ud This portable 129Xe hyperpolariser system could form the basis of a cost-effective platform for wider clinical dissemination and multicentre evaluation of 129Xe lung MR imaging. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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