| Autor: |
Edwards, Nicola C., Steeds, Richard P., Stewart, Paul M., Ferro, Charles J., Townend, Jonathan N. |
| Jazyk: |
angličtina |
| Předmět: |
|
| Zdroj: |
Journal of the American College of Cardiology. (6):505-512 |
| ISSN: |
0735-1097 |
| DOI: |
10.1016/j.jacc.2009.03.066 |
| Popis: |
ObjectivesWe sought to determine whether the addition of spironolactone to angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) improves left ventricular mass and arterial stiffness in early-stage chronic kidney disease (CKD).BackgroundChronic kidney disease is associated with a high risk of cardiovascular disease and a high prevalence of left ventricular hypertrophy and arterial stiffness that confer an adverse prognosis. It is believed that these abnormalities are in part a result of activation of the renin-angiotensin-aldosterone system.MethodsAfter an active run-in phase with spironolactone 25 mg once daily, 112 patients with stage 2 and 3 CKD with good blood pressure control (mean daytime ambulatory blood pressure |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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