| Autor: |
Demirkan, A., van Duijn, C.M., Ugocsai, P., Isaacs, A., Pramstaller, P.P., Liebisch, G., Wilson, J.F., Johansson, A., Rudan, I., Aulchenko, Y.S., Kirichenko, A.V., Janssens, A.C.J.W., Jansen, R.C., Gnewuch, C., Domingues, F.S., Pattaro, C., Wild, S.H., Jonasson, I., Polasek, O., Zorkoltseva, I.V., Hofman, A., Karssen, L.C., Struchalin, M., Floyd, J., Igl, W., Biloglav, Z., Broer, L., Pfeufer, A., Pichler, I., Campbell, S., Zaboli, G., Kolcic, I., Rivadeneira, F., Huffman, J., Hastie, N.D., Uitterlinden, A., Franke, L., Franklin, C.S., Vitart, V., Nelson, C.P., Preuss, M., Bis, J.C., O'Donnell, C.J., Franceschini, N., Witteman, J.C.M., Axenovich, T., Oostra, B.A., Meitinger, T., Hicks, A.A., Hayward, C., Wright, A.F., Gyllensten, U., Campbell, H., Schmitz, G., Consortium, EUROSPAN |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| ISSN: |
1553-7390 |
| Popis: |
Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a number of enzymatic processes, membrane formation, and cell signalling. Disruption of their metabolism leads to several diseases, with diverse neurological, psychiatric, and metabolic consequences. A large number of phospholipid and sphingolipid species can be detected and measured in human plasma. We conducted a meta-analysis of five European family-based genome-wide association studies (N = 4034) on plasma levels of 24 sphingomyelins (SPM), 9 ceramides (CER), 57 phosphatidylcholines (PC), 20 lysophosphatidylcholines (LPC), 27 phosphatidylethanolamines (PE), and 16 PE-based plasmalogens (PLPE), as well as their proportions in each major class. This effort yielded 25 genome-wide significant loci for phospholipids (smallest P-value = 9.88x10(-204)) and 10 loci for sphingolipids (smallest P-value = 3.10x10(-57)). After a correction for multiple comparisons (P-value |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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