| Autor: |
Grenha, R, Levdikov, V M, Fogg, M J, Blagova, E V, Brannigan, J A, Wilkinson, A.J., Wilson, K S |
| Jazyk: |
angličtina |
| Rok vydání: |
2005 |
| ISSN: |
1744-3091 |
| Popis: |
Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since these are recognized as potential targets in antibacterial therapy. Purine nucleoside phosphorylase is a key enzyme in the purine-salvage pathway. The crystal structure of purine nucleoside phosphorylase (DeoD) from B. anthracis has been solved by molecular replacement at 2.24 Å resolution and refined to an R factor of 18.4%. This is the first report of a DeoD structure from a Gram-positive bacterium. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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