| Autor: |
Kyritsi, Eleni Magdalini, Dimitriadis, Georgios K., Angelousi, Anna, Mehta, Hiten, Shad, Amjad, Mytilinaiou, Maria, Kaltsas, Gregory, Randeva, Harpal S. |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| ISSN: |
1365-2362 |
| Popis: |
Background\ud \ud To identify a serum prolactin (PRL) cut‐off value indicative of a PRL‐producing adenoma in women with Polycystic Ovarian Syndrome (PCOS) and hyperprolactinemia and characterize such patients.\ud \ud Materials and methods\ud \ud In the present retrospective case‐control study the medical records of 528 PCOS women were reviewed. Pituitary magnetic resonance imaging (MRI) was performed in PCOS patients with PRL levels ≥94.0 ng/mL and/or symptoms suspicious of a pituitary adenoma (PA). Prolactinoma diagnosis was made in the presence of an MRI‐identifiable PA with biochemical and radiological response to dopamine agonists. Receiver operating characteristic (ROC) curve analysis was performed to determine a serum PRL threshold that could identify hyperprolactinemic PCOS subjects with prolactinomas. Clinical, metabolic and endocrine parameters were also analysed.\ud \ud Results\ud \ud Among 528 patients with PCOS, 60 (11.4%) had elevated PRL levels. Of 44 (73.3%) patients who had pituitary imaging, 19 had PAs, 18 normal MRI and 7 other abnormalities. Patients harboring prolactinomas had significantly higher PRL levels compared to patients without adenomas (median PRL 95.4 vs. 49.2 ng/mL, p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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