| Autor: |
Ranatunga, Medhavi, Rai, Rajeev, Richardson, Simon C. W., Dyer, Paul D. R., Harbige, Laurence, Deacon, Andrew, Pecorino, Lauren, Getti, Giulia T. M. |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| ISSN: |
1742-4658 |
| Popis: |
Development of human leishmaniasis is dependent on the ability of intracellular Leishmania parasites to spread and enter macrophages. The mechanism through which free promastigotes and amastigotes bind and enter host macrophages has been previously investigated; however, little is known about intracellular trafficking and cell-to-cell spreading. In this study, the mechanism involved in the spreading of Leishmania aethiopica and Leishmania mexicana was investigated. A significant increase in phosphatidylserine (PS) exhibition, cytochrome C release, and active caspase-3 expression was detected (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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