| Autor: |
Clamp, A.R., Blackhall, F., Vasey, P., Soukop, M., Coleman, R., Halbert, G., Robson, L., Jayson, G.C., Canc Res UK Phase I II Comm |
| Jazyk: |
angličtina |
| Rok vydání: |
2003 |
| ISSN: |
0007-0920 |
| Popis: |
Bryostatin-1 is a macrocyclic lactone whose main mechanism of action is protein kinase C modulation. We investigated its activity as a weekly 24-h infusion in recurrent ovarian carcinoma. In all, 17 patients were recruited and 11 had chemotherapy-resistant disease as defined by disease progression within 4 months of last cytotoxic therapy. All were evaluable for toxicity and 14 for response. There were no disease responses and the main toxicity was myalgia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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