| Autor: |
Leong, KMW, Ng, FS, Shun-Shin, MJ, Koa-Wing, M, Qureshi, N, Whinnett, ZI, Linton, NF, Lefroy, D, Francis, DP, Harding, SE, Davies, DW, Peter, NS, Lim, PB, Behr, E, Lambiase, PD, Varnava, A, Kanagaratnam, P |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| ISSN: |
1532-2092 |
| Popis: |
AIMS : Rate adaptation of the action potential ensures spatial heterogeneities in conduction across the myocardium are minimized at different heart rates providing a protective mechanism against ventricular fibrillation (VF) and sudden cardiac death (SCD), which can be quantified by the ventricular conduction stability (V-CoS) test previously described. We tested the hypothesis that patients with a history of aborted SCD due to an underlying channelopathy or cardiomyopathy have a reduced capacity to maintain uniform activation following exercise. METHODS AND RESULTS : Sixty individuals, with (n = 28) and without (n = 32) previous aborted-SCD event underwent electro-cardiographic imaging recordings following exercise treadmill test. These included 25 Brugada syndrome, 13 hypertrophic cardiomyopathy, 12 idiopathic VF, and 10 healthy controls. Data were inputted into the V-CoS programme to calculate a V-CoS score that indicate the percentage of ventricle that showed no significant change in ventricular activation, with a lower score indicating the development of greater conduction heterogeneity. The SCD group, compared to those without, had a lower median (interquartile range) V-CoS score at peak exertion [92.8% (89.8-96.3%) vs. 97.3% (94.9-99.1%); P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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