| Autor: |
Zhukova, G., Shikhliarova, A., Petrosyan, V., Gudzkova, T., Bragina, M., Barteneva, T., Shirnina, E. |
| Jazyk: |
angličtina |
| Zdroj: |
European Journal of Cancer Supplements. (1):72 |
| ISSN: |
1359-6349 |
| DOI: |
10.1016/j.ejcsup.2015.08.127 |
| Popis: |
BackgroundIt has previously been shown that additional local electromagnetic impact on the tumor en-hances the systemic antitumor effect of low-intensity electromagnetic radiation (EMR) used in the activation therapy regimes designed by Garkavi L.H. et al. (1990–2008). At the same time the question of the influence of weak EMR, applied to the peritumoral area, on the tumor development has not been studied.The aim of the study was to investigate the changes in the tumor caused by low-intensity microwave electromagnetic radiation of bioeffective frequency that acted on the head and peritumoral zone.Materials and methodsThe effects of resonance radiation (RR) with frequency corresponding to that of one of the water-containing medium radiations – 1GHz (“SPE-effect”) – were studied on 53 adult male outbred white rats with transplantable sarcoma 45. Special anticancer agents were not used. The power flux density of RR was less than 1μW/cm2, surface area of the emitter – 4cm2, 3–10min. exposure depending on algorithms of the activation therapy. RR exposure in different groups of animals was localized to the head only, or to the peri-tumoral area only, or successively to the head and peritumoral area (“double” exposure). The course lasted for 4weeks. The exposure effect was assessed according to the dynamics of the tumor size and results of the light and electron microscopy analysis of tumor changes (JEOL JEM-1011, Japan).ResultsThe effect of RR in different groups of animals depended on the exposure localization. Central systemic exposure was decisive. The group receiving RR localized to the head showed regression of the tumor or inhibition of its growth in 60% of animals – almost complete tumor regression in 10% and tumor growth inhibition by 70% in the rest cases. RR to the peritumoral area did not show significant influence on the tumor development, while it increased antitumor effect of the central exposure (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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