| Autor: |
Larkin, D., De Laat, B., Jenkins, P. V., Bunn, J., Craig, Alister, Terraube, V., Preston, R. J. S., Donkor, C., Grau, G. E., Van Mourik, J. A., O'Donnell, J. S. |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| ISSN: |
1553-7374 |
| Popis: |
Plasmodium falciparum infection results in adhesion of infected erythrocytes to blood vessel endothelium, and acute endothelial cell activation, together with sequestration of platelets and leucocytes. We have previously shown that patients with severe infection or fulminant cerebral malaria have significantly increased circulatory levels of the adhesive glycoprotein von Willebrand factor (VWF) and its propeptide, both of which are indices of endothelial cell activation. In this prospective study of patients from Ghana with severe (n = 20) and cerebral (n = 13) P. falciparum malaria, we demonstrate that increased plasma VWF antigen (VWF:Ag) level is associated with disproportionately increased VWF function. VWF collagen binding (VWF:CB) was significantly increased in patients with cerebral malaria and severe malaria (medians 7.6 and 7.0 lU/ml versus 1.9 IU/ml;p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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