Investigating inherent functional differences between human cardiac fibroblasts cultured from nondiabetic and Type 2 diabetic donors

Autor:	Sedgwick, B, Riches, K, Bageghni, SA, O'Regan, DJ, Porter, KE, Turner, NA
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	endocrine system diseases nutritional and metabolic diseases
ISSN:	1054-8807
Popis:	Type 2 diabetes mellitus (T2DM) promotes adverse myocardial remodeling and increased risk of heart failure; effects that can occur independently of hypertension or coronary artery disease. As cardiac fibroblasts (CFs) are key effectors of myocardial remodeling, we investigated whether inherent phenotypic differences exist in CF derived from T2DM donors compared with cells from nondiabetic (ND) donors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::9592910d8aafb70788c60699b1a87954 Zobrazit plný text záznamu Full Text from ScienceDirect