| Autor: |
Molloy, S.F., Bradley, J., Karunaharan, N., Mputu, M., Stone, N., Phulusa, J., Chawinga, C., Gaskell, K., Segula, D., Ming, D., Peirse, M., Chanda, D., Lakhi, S., Loyse, A., Kanyama, C., Heyderman, R.S., Harrison, T.S. |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| ISSN: |
0269-9370 |
| Popis: |
We assessed the effect of fluconazole 1200 mg/day on QT interval in cryptococcal meningitis patients. Mean QTc change from baseline to day 7 was 10.1ms (IQR: -28 to 46) in the fluconazole treatment group and -12.6ms (IQR: -39 to 13.5) in those not taking fluconazole (p = 0.04). No significant increase in QTc measurements over 500ms was observed with fluconazole. Nevertheless, it remains important to correct any electrolyte imbalance and avoid concomitant drugs that may increase QTc. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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