| Autor: |
Welsh, P., Doolin, O., McConnachie, A., Boulton, E., McNeil, G., Macdonald, H., Hardcastle, A., Hart, C., Upton, M., Watt, G., Sattar, N. |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| ISSN: |
0021-972X |
| Popis: |
Context: Observational studies relating circulating 25-hydroxyvitamin D (25OHD) and dietary vitamin D intake to cardiovascular disease (CVD) have reported conflicting results.\ud Objective: Our objective was to investigate the association of 25OHD, dietary vitamin D, PTH, and adjusted calcium with CVD and mortality in a Scottish cohort.\ud Design and Setting: TheMIDSPAN Family Study is a prospective study of 1040 men and 1298 women from the West of Scotland recruited in 1996 and followed up for a median 14.4 yr.\ud Participants: Locally resident adult offspring of a general population cohort were recruited from 1972–1976.\ud Main Outcome Measures: CVD events (n = 416) and all-cause mortality (n=100) were evaluated.\ud Results: 25OHD was measured using liquid chromatography-tandem mass spectrometry in available plasma (n=2081). Median plasma 25OHD was 18.6 ng/ml, and median vitamin D intake was\ud 3.2 µ g/d (128 IU/d). Vitamin D deficiency (25OHD\ud Conclusion: Vitamin D deficiency was not associated with risk of CVD in this cohort with very low 25OHD. Future trials of vitamin D supplementation in middle-aged cohorts should be powered to detect differences inmortality outcomes as well as CVD.(J Clin EndocrinolMetab97: 0000 –0000, 2012) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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