| Autor: |
Morris, P.D., Gosling, R., Zwierzak, I., Evans, H., Aubiniere-Robb, L., Czechowicz, K., Evans, P.C., Hose, D.R., Lawford, P.V., Narracott, A., Gunn, J.P. |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| ISSN: |
0008-6363 |
| Popis: |
Aims\ud \ud Ischaemic heart disease is the reduction of myocardial blood flow, caused by epicardial and/or microvascular disease. Both are common and prognostically important conditions, with distinct guideline-indicated management. Fractional flow reserve (FFR) is the current gold-standard assessment of epicardial coronary disease, but is only a surrogate of flow and only predicts percentage flow changes. It cannot assess absolute (volumetric) flow or microvascular disease. The aim of this study was to develop and validate a novel method that predicts absolute coronary blood flow and microvascular resistance (MVR) in the catheter laboratory.\ud \ud \ud Methods and Results\ud \ud A computational fluid dynamics (CFD) model was used to predict absolute coronary flow (QCFD) and coronary microvascular resistance (MVR) using data from routine invasive angiography and pressure-wire assessment. QCFD was validated in an in vitro flow circuit which incorporated patient-specific, 3-D printed coronary arteries; and then in vivo, in patients with coronary disease. In vitro, QCFD agreed closely with the experimental flow over all flow rates (bias +2.08 mL/min; 95% CI (error range) -4.7 to + 8.8 mL/min; R2=0.999, p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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