| Autor: |
Gupta, A, Monteferrante, C, Rasina, D, Leitis, G, Randall, CP, Tomlinson, JH, Jirgensons, A, Goessens, WHF, Hays, JP, O'Neill, AJ |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| ISSN: |
1098-6596 |
| Popis: |
GSK2251052 is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS) that has been evaluated in Phase II clinical trials. Here we report the identification of a clinical isolate of Staphylococcus aureus that exhibits reduced susceptibility to GSK2251052 without prior exposure to the compound, and demonstrate that this phenotype is attributable to a single amino acid polymorphism (P329) within the editing domain of LeuRS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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