| Autor: |
Mather, Rebecca L., Venalainen, Erik, Pucci, Perla, Lin, Dong, Xue, Hui, Wang, Yuzhuo, Crea, Francesco |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Zdroj: |
3rd International Cancer Symposium, Cancer Research Center of Lyon (CRCL) |
| Popis: |
Neuroendocrine prostate cancer (NEPC) is an incurable, androgen receptor (AR)-negative disease that originates from AR-positive adenocarcinomas. Loss or mutation of the AR renders androgen deprivation therapy ineffective and presents a therapeutic problem. Currently, incidence of NEPC is rising and new therapeutic strategies are urgently needed.\ud \ud LncRNAs are some of the most differentially regulated transcripts in cancer, but are largely unexplored. To investigate the expression of lncRNAs in NEPC, we used patient-derived xenografts (PDXs) developed at the Living Tumour Laboratory (LTL). These PDXs retain the histology, genetic, and epigenetic features of their human counterparts. For this study, we employed the first-in-field animal model of trans-differentiation from hormone-sensitive prostate adenocarcinoma (LTL331) to NEPC (LTL331R). Using RNASeq we generated a shortlist of lncRNAs which were up-regulated in NEPC (fold change>4, FDR |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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