Vascular patterning of subcutaneous mouse fibrosarcomas expressing individual VEGF isoforms can be differentiated using angiographic optical coherence tomography

Autor: Byers, R.A., Fisher, M., Brown, N.J., Tozer, G.M., Matcher, S.J.
Jazyk: angličtina
Rok vydání: 2017
ISSN: 2156-7085
Popis: Subcutaneously implanted experimental tumors in mice are commonly used in\ud cancer research. Despite their superficial location, they remain a challenge to image noninvasively\ud at sufficient spatial resolution for microvascular studies. Here we evaluate the\ud capabilities of optical coherence tomography (OCT) angiography for imaging such tumors\ud directly through the murine skin in-vivo. Datasets were collected from mouse tumors derived\ud from fibrosarcoma cells genetically engineered to express only single splice variant isoforms\ud of vascular endothelial growth factor A (VEGF); either VEGF120 or VEGF188 (fs120 and\ud fs188 tumors respectively). Measured vessel diameter was found to be significantly (p
Databáze: OpenAIRE