| Autor: |
Volz, E, Mishra, S, Chand, M, Barrett, JC, Johnson, R, Geidelberg, L, Hinsley, WR, Laydon, DJ, Dabrera, G, O’Toole, Á, Amato, R, Ragonnet-Cronin, M, Harrison, I, Jackson, B, Ariani, CV, Boyd, O, Loman, NJ, McCrone, JT, Gonçalves, S, Jorgensen, D, Myers, R, Hill, V, Jackson, DK, Gaythorpe, K, Groves, N, Sillitoe, J, Kwiatkowski, DP, Koshy, C, Ash, A, Wise, E, Moore, N, Mori, M, Cortes, N, Lynch, J, Kidd, S, Fairley, DJ, Curran, T, McKenna, JP, Adams, H, Fraser, C, Golubchik, T, Bonsall, D, Hassan-Ibrahim, MO, Malone, CS, Cogger, BJ, Wantoch, M, Reynolds, N, Warne, B, Maksimovic, J, Spellman, K, McCluggage, K, John, M, Beer, R, Afifi, S, Morgan, S, Marchbank, A, Price, A, Kitchen, C, Gulliver, H, Merrick, I, Southgate, J, Guest, M, Munn, R, Workman, T, Connor, TR, Fuller, W, Bresner, C, Snell, LB, Patel, A, Charalampous, T, Nebbia, G, Batra, R, Edgeworth, J, Robson, SC, Beckett, AH, Aanensen, DM, Underwood, AP, Yeats, CA, Abudahab, K, Taylor, BEW, Menegazzo, M, Clark, G, Smith, W, Khakh, M, Fleming, VM, Lister, MM, Howson-Wells, HC, Berry, L, Boswell, T, Joseph, A, Willingham, I, Jones, C, Holmes, C, Bird, P, Helmer, T, Fallon, K, Tang, J, Raviprakash, V, Campbell, S, Sheriff, N |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| ISSN: |
0028-0836 |
| Popis: |
The SARS-CoV-2 lineage B.1.1.7, designated variant of concern (VOC) 202012/01 by Public Health England1, was first identified in the UK in late summer to early autumn 20202. Whole-genome SARS-CoV-2 sequence data collected from community-based diagnostic testing for COVID-19 show an extremely rapid expansion of the B.1.1.7 lineage during autumn 2020, suggesting that it has a selective advantage. Here we show that changes in VOC frequency inferred from genetic data correspond closely to changes inferred by S gene target failures (SGTF) in community-based diagnostic PCR testing. Analysis of trends in SGTF and non-SGTF case numbers in local areas across England shows that B.1.1.7 has higher transmissibility than non-VOC lineages, even if it has a different latent period or generation time. The SGTF data indicate a transient shift in the age composition of reported cases, with cases of B.1.1.7 including a larger share of under 20-year-olds than non-VOC cases. We estimated time-varying reproduction numbers for B.1.1.7 and co-circulating lineages using SGTF and genomic data. The best-supported models did not indicate a substantial difference in VOC transmissibility among different age groups, but all analyses agreed that B.1.1.7 has a substantial transmission advantage over other lineages, with a 50% to 100% higher reproduction number. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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