Electrospun aniline-tetramer-co-polycaprolactone fibers for conductive, biodegradable scaffolds

Autor:	Guex, A. G., Spicer, C. D., Armgarth, A., Gelmi, A., Humphrey, E. J., Terracciano, C. M., Harding, S. E., Stevens, M. M.
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	technology industry and agriculture equipment and supplies
ISSN:	2159-6859
Popis:	Conjugated polymers have been proposed as promising materials for scaffolds in tissue engineering applications. However, the restricted processability and biodegradability of conjugated polymers limit their use for biomedical applications. Here we synthesized a block-co-polymer of aniline tetramer and PCL (AT-PCL), and processed it into fibrous non-woven scaffolds by electrospinning. We showed that fibronectin (Fn) adhesion was dependent on the AT-PCL oxidative state, with a reduced Fn unfolding length on doped membranes. Furthermore, we demonstrated the cytocompatibility and potential of these membranes to support the growth and osteogenic differentiation of MC3T3-E1 cells over 21 days.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::58f7db5255e85c313de76c5975a5a779 https://eprints.whiterose.ac.uk/135448/1/electrospun_anilinetetramercopolycaprolactone_fibers_for_conductive_biodegradable_scaffolds_1.pdf Zobrazit plný text záznamu Full text from SpringerLink