| Autor: |
Hartmann, Daniel, von Figura, Guido, Song, Zhangfa, Harden, Sharon, Scott, Lucy C, Evans, TR Jeffry, Rudolph, Karl Lenhard, Bilsland, Alan E, Keith, W Nicol |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| ISSN: |
1479-6694 |
| Popis: |
Background:N-acetyl-glucosaminidase (NAG) is a potential marker of genotoxicity. We retrospectively analyzed plasma NAG and clinico-pathologic features in advanced gastrointestinal adenocarcinoma patients. Methods: Plasma from 118 patients and 51 healthy volunteers was analyzed for associations between NAG levels and age, disease presence, stage, treatment responses and survival. Results:Pretreatment NAG correlated with age but was independently increased in metastatic versus locally advanced disease, particularly in gastric/esophageal patients. NAG was also associated with reduced overall survival. In subgroup analysis, increased NAG activity between day 1 and 2 of chemotherapy cycle 1 correlated with treatment response.Conclusion:We demonstrated that NAG correlates with gastrointestinal cancer outcomes. Further studies are required to determine if plasma markers of genotoxicity can be useful for disease monitoring. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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