The PREVIEW intervention study: Results from a 3-year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes

Autor: Raben, Anne, Vestentoft, Pia Siig, Brand?Miller, Jennie, Jalo, Elli, Drummen, Mathjis, Simpson, Liz, Martinez, J. Alfredo, Handjieva?Darlenska, Teodora, Stratton, Gareth, Huttunen?Lenz, Maija, Lam, Tony, Sundvall, Jouko, Muirhead, Roslyn, Poppitt, Sally, Ritz, Christian, Westerterp?Plantenga, Margriet, Taylor, Moira A., Carretero, Santiago Navas, Handjiev, Svetoslav, McNarry, Melitta A, Hansen, Sylvia, Brodie, Shannon, Silvestre, Marta P, Adam, Tanja C, Macdonald, Ian A, San?Cristobal, Rodrigo, Boyadjieva, Nadka, Mackintosh, Kelly A, Schlicht, Wolfgang, Liu, Amy, Larsen, Thomas M, Fogelholm, Mikael
Jazyk: angličtina
Rok vydání: 2021
Předmět:
ISSN: 1462-8902
1463-1326
Popis: © 2020 John Wiley & Sons Ltd Aim: To compare the impact of two long-term weight-maintenance diets, a high protein (HP) and low glycaemic index (GI) diet versus a moderate protein (MP) and moderate GI diet, combined with either high intensity (HI) or moderate intensity physical activity (PA), on the incidence of type 2 diabetes (T2D) after rapid weight loss. Materials and Methods: A 3-year multicentre randomized trial in eight countries using a 2 x 2 diet-by-PA factorial design was conducted. Eight-week weight reduction was followed by a 3-year randomized weight-maintenance phase. In total, 2326 adults (age 25-70 years, body mass index ≥ 25 kg/m2) with prediabetes were enrolled. The primary endpoint was 3-year incidence of T2D analysed by diet treatment. Secondary outcomes included glucose, insulin, HbA1c and body weight. Results: The total number of T2D cases was 62 and the cumulative incidence rate was 3.1%, with no significant differences between the two diets, PA or their combination. T2D incidence was similar across intervention centres, irrespective of attrition. Significantly fewer participants achieved normoglycaemia in the HP compared with the MP group (P
Databáze: OpenAIRE
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