| Autor: |
Halle, JL, Pena, GS, Paez, HG, Castro, AJ, Rossiter, HB, Visavadiya, NP, Whitehurst, MA, Khamoui, AV |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| ISSN: |
0363-6119 |
| Popis: |
In addition to skeletal muscle dysfunction, cancer cachexia is a systemic disease involving remodeling of non-muscle organs such as adipose and liver. Impairment of mitochondrial function is associated with multiple chronic diseases. The tissue-specific control of mitochondrial function in cancer cachexia is not well-defined. This study determined mitochondrial respiratory capacity and coupling control of skeletal muscle, white adipose tissue (WAT), and liver in colon-26 (C26) tumor-induced cachexia. Tissues were collected from PBS-injected weight-stable mice, C26 weight-stable mice, and C26 mice with moderate (10% weight loss) and severe cachexia (20% weight loss). The respiratory control ratio (RCR, an index of OXPHOS coupling efficiency) was low in WAT during the induction of cachexia, due to high non-phosphorylating LEAK respiration. Liver RCR was low in C26 weight-stable and moderately cachexic mice due to reduced OXPHOS. Liver RCR was further reduced with severe cachexia, where Ant2 but not Ucp2 expression was increased. Ant2 was inversely correlated with RCR in the liver (r=-0.547, p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
