| Autor: |
Weatherley, N.D., Stewart, N.J., Chan, H.-F., Austin, M., Smith, L.J., Collier, G., Rao, M., Marshall, H., Norquay, G., Renshaw, S.A., Bianchi, S.M., Wild, J.M. |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| ISSN: |
0040-6376 |
| Popis: |
Prognosticating idiopathic pulmonary fibrosis (IPF) is challenging, in part due to a lack of sensitive biomarkers. A recent article in Thorax described how hyperpolarised xenon magnetic resonance spectroscopy may quantify regional gas exchange in IPF lungs. In a population of patients with IPF, we find that the xenon signal from red blood cells diminishes relative to the tissue/plasma signal over a 12-month time period, even when the diffusion factor for carbon monoxide is static over the same time period. We conclude that hyperpolarised 129Xe MR spectroscopy may be sensitive to short-term changes in interstitial gas diffusion in IPF. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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