Peroxisome proliferator-activated receptor ? agonism attenuates endotoxaemia-induced muscle protein loss and lactate accumulation in rats

Autor:	Crossland, Hannah, Constantin-Teodosiu, Dumitru, Gardiner, Sheila M., Greenhaff, PaulL.
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	sepsis inflammation muscle atrophy muscle insulin resistance
ISSN:	0143-5221 1470-8736
Popis:	The peroxisome proliferator-activated receptor γ (PPARγ) agonist rosiglitazone (Rosi) appears to provide protection against organ dysfunction during endotoxaemia. We examined the potential benefits of Rosi on skeletal muscle protein maintenance and carbohydrate metabolism during lipopolysaccharide (LPS)-induced endotoxaemia. Sprague-Dawley rats were fed either standard chow (control) or standard chow containing Rosi (8.5±0.1 mg.kg-1.day-1) for two weeks before and during 24 h continuous intravenous infusion of LPS (15 μg.kg-1.h-1) or saline. Rosi blunted LPS-induced increases in muscle tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) mRNA by 70% (P
Databáze:	OpenAIRE
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