Effect of acute and chronic sunitinib treatment on cardiac function and CaMKII
| Autor: | Mooney, L, Skinner, M, Coker, S. J., Currie, S. |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| ISSN: | 1476-5381 |
| Popis: | Calcium/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is an important regulator of cardiac contractile function and dysfunction and may be an unwanted secondary target for anti-cancer drugs such as sunitinib and imatinib that have been reported to alter cardiac performance. This study aimed to determine whether anti-cancer kinase inhibitors may affect CaMKII activity and expression when administered in vivo. |
| Databáze: | OpenAIRE |
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