Effect of acute and chronic sunitinib treatment on cardiac function and CaMKII

Autor: Mooney, L, Skinner, M, Coker, S. J., Currie, S.
Jazyk: angličtina
Rok vydání: 2015
Předmět:
ISSN: 1476-5381
Popis: Calcium/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is an important regulator of cardiac contractile function and dysfunction and may be an unwanted secondary target for anti-cancer drugs such as sunitinib and imatinib that have been reported to alter cardiac performance. This study aimed to determine whether anti-cancer kinase inhibitors may affect CaMKII activity and expression when administered in vivo.
Databáze: OpenAIRE