| Autor: |
Nadarassan, D K, Loni, A, Kelly, c, O’Brien, H, Caffull, E, Webb, K, Canham, L T, Maniruzamman, M, Trivedi, Vivek, Douroumis, Dennis |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Controlled Release Society Meeting 2015 |
| Popis: |
Biodegradable porous silicon (pSi) is under assessment for the controlled release of both proteins and poorly-soluble API formulations. Super-critical drying of ultrahigh porosity (90%) porous silicon is shown here to preserve much higher mesopore volumes (up to 4mL/g) and surface areas (up to 600m2/g) than achievable with standard air drying. The payloads and physical state of the model drug (S) (+) ibuprofen, as loaded within a super-critically dried porous silicon carrier matrix, were quantified and assessed using TGA, DSC, cross-sectional EDX, XRD, Raman mapping and FT-IR. In-vitro biodegradability was assessed using molybdenum blue assay and drug release using RP-HPLC. Entrapped drug payloads as high as 70%w/w have been achieved, substantially higher than values reported for other mesoporous materials. The entrapped (S) (+) ibuprofen showed faster release than bulk (S) (+) ibuprofen. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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