Treating a human neuroectodermal cell line with retinoic acid induces the appearance of neuron-like voltage-gated ionic currents

Autor:	S. Santillo, A. Polverino, E. Guatteo, P. Sorrentino, A. Mafiini, R. Piscitelli, N. Mercuri, V. Di Maio, G. Sorrentino
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	retinoic acid whole cell patch-clamp neuronal differentiation
Zdroj:	XLVll Congress of the ltalian Neurological Society, pp. S383–S383, Napoli, Italia, 14-17/10/2017 info:cnr-pdr/source/autori:S. Santillo, A. Polverino, E. Guatteo, P. Sorrentino, A. Mafiini, R. Piscitelli, N. Mercuri, V. Di Maio, G. Sorrentino/congresso_nome:XLVll Congress of the ltalian Neurological Society/congresso_luogo:Napoli, Italia/congresso_data:14-17%2F10%2F2017/anno:2017/pagina_da:S383/pagina_a:S383/intervallo_pagine:S383–S383
Popis:	TB cells are a novel human neuroectodermal cell line ìsolated from the cerebrospinalfluid (CSF) of a patient affectedby primary leptomeningeal melanomatosis. Immunological techniques after 10 microM retinoic acid (RA) treatment showed morphological differentiation in a neuronal-like phenotype. We wanted characterize the basic electrophysiological properties in order to determine if RA treatment induces the appearance of voltage-dependent currents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=cnr_________::f6851cf8b922911de2fac00f8f12891c https://publications.cnr.it/doc/376798 Zobrazit plný text záznamu