Bioartificial endocrine organs: at the cutting edge of translational research in endocrinology
| Autor: | Toni R, Bassi E, Zini N, Zamparelli A, Barbaro F, Dallatana D, Mosca S, Lippi G, Spaletta G, Bassoli E, Denti L, Gatto A, Parrilli A, Fini M, Giardino R, Sandri M, Sprio S, Tampieri A. |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Bio-inspired Regenerative Medicine: Materials, Processes and Clinical Applications, edited by Sprio, Simone; Tampieri, Anna. Singapore: Pan Stanford Publishing, 2016 info:cnr-pdr/source/autori:Toni R, Bassi E, Zini N, Zamparelli A, Barbaro F, Dallatana D, Mosca S, Lippi G, Spaletta G, Bassoli E, Denti L, Gatto A, Parrilli A, Fini M, Giardino R, Sandri M, Sprio S, Tampieri A./titolo:Bioartificial endocrine organs: at the cutting edge of translational research in endocrinology/titolo_volume:Bio-inspired Regenerative Medicine: Materials, Processes and Clinical Applications/curatori_volume:Sprio, Simone; Tampieri, Anna/editore: /anno:2016 |
| Popis: | Bioartificial endocrine organs comprise classical endocrine glands, and soft (parenchyma) and hard (mineralized) tissue organs involved in endocrine-metabolic regulation. These bioconstructs are one of the newest promises of regenerative medicine, but their bioengineering "on the laboratory bench" and thus, outside the living body (i.e. ex situ) remains a substantial challenge [1, 2]. Based on current concepts [3-5], bioartificial endocrine organs can be engineered ex situ using macroscopic, three-dimensional (3D) scaffolds that mimic the 3D architecture of the native, organ stromal support (here coined organomorphism) reproduced with either natural or synthetic biomaterials. Once pluripotent stem cells, tissue-committed progenitors, and differentiated primary cells are seeded and co-cultured with the organomorphic scaffold, their self-assembly is expected up to the formation of a 3D macroscopic, functional and immuno-tolerant organ, replicating the native one. However, 3D systems exhibiting appropriate flow and trophic performance (bioreactor) are required to maximize homing, survival, growth, and differentiation/transdifferentiation of seeded elements [3, 6, 7]. Embryonic stem cells (ESCs) and induced pluripotent stem cells are also raising hopes as valuable sources to bioengineer human bioartificial viscera [8, 9]; thus, in the near future they may become another option to reconstruct ex situ bioartificial endocrine organs. |
| Databáze: | OpenAIRE |
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