Characterization of the human salivary basic praline-rich protein complex by a proteomic approach
| Autor: | Messana I., Cabras T., Inzitari R., Lupi A., Zuppi C., Olmi C., Fadda M.B., Cordaro M., Giardina B., Castagnola M. |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Zdroj: | Journal of proteome research 3(4) (2004): 792–800. info:cnr-pdr/source/autori:Messana I., Cabras T., Inzitari R., Lupi A., Zuppi C., Olmi C., Fadda M.B., Cordaro M., Giardina B., Castagnola M./titolo:Characterization of the human salivary basic praline-rich protein complex by a proteomic approach/doi:/rivista:Journal of proteome research (Print)/anno:2004/pagina_da:792/pagina_a:800/intervallo_pagine:792–800/volume:3(4) |
| Popis: | Thirteen samples of human normal whole saliva were analyzed by RP-HPLC-ESI-MS and MALDI-TOF-MS to investigate the basic proline-rich protein complex. Between known basic-PRPs the P-B, P-C (or IB-8b), P-D (or IB-5), P-E (or IB-9), P-F (or IB-8), P-H (or IB-4), IB-6,II-2, IB-1, and IB-8a glucosylated were identified, whereas the II-1, IB-7, PA, and D1-A peptides were not detected. Some detected masses not attributable to known basic-PRPs were putatively ascribed to II-2 and IB-1 nonphosphorylated, II-2 and IB-1 missing the C-terminal arginine residue, and the 1-62 fragment of IB-6, named P-J peptide. A correlation matrix analysis revealed a cluster of correlation among all the basic PRF's (apart from the P-B peptide) which is in agreement with their common parotid origin. |
| Databáze: | OpenAIRE |
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