Detection of high levels of Survivin-IgM immune complex in sera from hepatitis C virus infected patients with cirrhosis
| Autor: | Matteucci C, Sorrentino R, Bellis L, Ettorre GM, Svicher V, Santoro R, Vennarecci G, Biasiolo A, Pontisso P, Scacciatelli D, Beneduce L, Sarrecchia C, Casalino P, Bernardini S, Pierimarchi P, Garaci E, Puoti C, Rasi G. |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Hepatology research (2013). doi:10.1111/hepr.12239 info:cnr-pdr/source/autori:Matteucci C, Sorrentino R, Bellis L, Ettorre GM, Svicher V, Santoro R, Vennarecci G, Biasiolo A, Pontisso P, Scacciatelli D, Beneduce L, Sarrecchia C, Casalino P, Bernardini S, Pierimarchi P, Garaci E, Puoti C, Rasi G./titolo:Detection of high levels of Survivin-IgM immune complex in sera from hepatitis C virus infected patients with cirrhosis./doi:10.1111%2Fhepr.12239/rivista:Hepatology research (Print)/anno:2013/pagina_da:/pagina_a:/intervallo_pagine:/volume |
| DOI: | 10.1111/hepr.12239 |
| Popis: | AIM: The identification and surveillance of patients with liver dysfunctions and the discovering of new disease biomarkers with high sensibility and specificity are needed in the clinical practice. Aim of this study was to investigate on the serological presence of circulating Survivin-IgM immune complex (IC) as potential biomarker of diverse phases of chronic liver diseases. METHODS: Serum levels of Survivin-IgM were measured using an ELISA standardized and validated in our laboratory in 262 individuals, including healthy subjects and patients with chronic hepatitis, cirrhosis and HCC. RESULTS: Survivin-IgM IC was lower in healthy subjects (median: 99.39 AU/ml, IQR=73.33-148.27) than in patients with chronic viral hepatitis (median: 148.03 AU/ml, IQR=86.75-333.82; p=0.002) or with cirrhosis (median: 371.00 AU/ml, IQR=106.07-1110.06; p |
| Databáze: | OpenAIRE |
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