Role of the p53 oncosuppressor gene family members in the expression regulation of the IGFBP3 gene
| Autor: | F. Marzano, MF Faienza, E. Sbisà, MF Caratozzolo, AM Ventura, A. Tullo, L. Cavallo |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Zdroj: | LWPES/ESPE 9th Joint Meeting Global Care in Pediatric Endocrinology, pp. 107, Praga, 2010 info:cnr-pdr/source/autori:F. Marzano, MF Faienza, E. Sbisà, MF Caratozzolo, AM Ventura, A. Tullo, L. Cavallo/congresso_nome:LWPES%2FESPE 9th Joint Meeting Global Care in Pediatric Endocrinology/congresso_luogo:Praga/congresso_data:2010/anno:2010/pagina_da:107/pagina_a:/intervallo_pagine:107 |
| Popis: | Insulin-like growth factors (IGFs), their common receptors (IGFIRs) and their binding proteins (IGFPBs) play a critical role in fetal and postnatal growth. Only exceptionally mutations or deletions of IGF-related genes have been reported in short children. For this reason, the attention has been focused on the functional study of IGF-related promoter genes in search of new regulatory elements and factors that might alter gene expression. Among these genes, IGFBP3 plays a key role because it transports more than 75% of serum IGFs, extends the half-life of IGFs and modulates their biological effects. In addition, IGFBP3 also has IGF-independent effects, including cell growth inhibition and induction of apoptosis. The literature reports that the IGFBP3 gene is a direct target of p53 and contains two p53 Responsive Elements (REs) located in intron 1 and intron 2: box A and box B, respectively. Moreover, it has been reported that ?Np63? down-regulates IGFBP3 expression. |
| Databáze: | OpenAIRE |
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