Study of neural cells on organic semiconductor ultra thin films
| Autor: | Eva Bystrenova, Ilaria Tonazzini, Pablo Stoliar, Pierpaolo Greco, Marta Jelitai, Adina Lazar, Martin Huth, Soumya Dutta, Chiara Dionigi, Marcello G. Cacace, Bert Nickel, Emilia Madarasz, Claudia Martini, Fabio Biscarini |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | 72. Annual Meeting of the DPG and DPG Spring Meeting of the Condensed Matter Division, Berlin, Berlin, February 25-29, 2008 info:cnr-pdr/source/autori:Eva Bystrenova, Ilaria Tonazzini, Pablo Stoliar, Pierpaolo Greco, Marta Jelitai, Adina Lazar, Martin Huth, Soumya Dutta, Chiara Dionigi, Marcello G. Cacace, Bert Nickel, Emilia Madarasz, Claudia Martini and Fabio Biscarini/congresso_nome:72. Annual Meeting of the DPG and DPG Spring Meeting of the Condensed Matter Division/congresso_luogo:Berlin/congresso_data:Berlin, February 25-29, 2008/anno:2008/pagina_da:/pagina_a:/intervallo_pagine |
| Popis: | Many technological advances are currently being developed for nano- fabrication, offering the ability to create and control patterns of soft materials. We report the deposition of cells on organic semiconductor ultra-thin films. This is a first step towards the development of active bio/non bio systems for electrical transduction. Thin films of pentacene, whose thickness was systematically varied, were grown by high vacuum sublimation. We report adhesion, growth, and differentiation of human astroglial cells and mouse neural stem cells on an organic semiconductor. Viability of astroglial cells in time was measured as a function of the roughness and the characteristic morphology of ultra thin organic film, as well as the features of the patterned molecules. Optical fluorescence microscope coupled to atomic force microscope was used to monitor the presence, density and shape of deposited cells. Neural stem cells remain viable, differentiate by retinoic acid and form dense neuronal networks. We have shown the possibility to integrate living neural cells on organic semiconductor thin films. Project EU-NMP-STRP 032652 BIODOT. |
| Databáze: | OpenAIRE |
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