Slow VO2: kinetics during moderate-intensity exercise as markers of lower metabolic stability and lower exercise tolerance
| Autor: | Grassi B. 1, Porcelli S, 2, 3, Salvadego D. 1, Zoladz J.A. 4. |
|---|---|
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | European journal of applied physiology 111 (2011): 345–355. info:cnr-pdr/source/autori:Grassi B. 1, Porcelli S, 2,3, Salvadego D. 1, Zoladz J.A. 4./titolo:Slow VO2: kinetics during moderate-intensity exercise as markers of lower metabolic stability and lower exercise tolerance/doi:/rivista:European journal of applied physiology (Print)/anno:2011/pagina_da:345/pagina_a:355/intervallo_pagine:345–355/volume:111 |
| Popis: | An analysis of previously published data obtained by our group on patients characterized by markedly slower pulmonary VO2 kinetics (heart transplant recipients, patients with mitochondrial myopathies, patients with McArdle disease) was carried out in order to suggest that slow VO2 kinetics should not be considered the direct cause, but rather a marker, of impaired exercise tolerance. For a given ATP turnover rate, faster (or slower) VO2 kinetics are associated with smaller (or greater) muscle [PCr] decreases. The latter, however, should not be taken per se responsible for the higher (or lower) exercise tolerance, but should be considered within the general concept of "metabolic stability". Good muscle metabolic stability at a given ATP turnover rate (~power output) is associated with relatively smaller decreases, compared to rest, in [PCr] and in the Gibbs free energy of ATP hydrolysis, as well as with relatively smaller increases in [Pi], [ADP(free)], [AMP(free)], and [IMP(free)], metabolites directly related to fatigue. Disturbances in muscle metabolic stability can affect muscle function in various ways, whereas good metabolic stability is associated with less fatigue and higher exercise tolerance. Smaller [PCr] decreases, however, are strictly associated with a faster VO2 kinetics. Thus, faster VO2 kinetics may simply be an "epiphenomenon" of a relatively higher metabolic stability, which would then represent the relevant variable in terms of fatigue and exercise tolerance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|