HCV eradication with IFN-based therapy does not completely restore gene expression in PBMCs from HIV/HCV-coinfected patients

Autor: Brochado, O, Martinez, I, Berenguer, J, Medrano, L, Gonzalez-Garcia, J, Jimenez-Sousa, MA, Carrero, A, Hontanon, V, Navarro, J, Guardiola, JM, Fernandez-Rodriguez, A, Resino, S, Domingo P., Esteban, Herminia
Rok vydání: 2021
Předmět:
Zdroj: JOURNAL OF BIOMEDICAL SCIENCE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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ISSN: 1021-7770
Popis: Objective To evaluate the impact of hepatitis C virus (HCV) elimination via interferon (IFN)-based therapy on gene expression profiles related to the immune system in HIV/HCV-coinfected patients. Methods We conducted a prospective study in 28 HIV/HCV-coinfected patients receiving IFN-based therapy at baseline (HIV/HCV-b) and week 24 after sustained virological response (HIV/HCV-f). Twenty-seven HIV-monoinfected patients (HIV-mono) were included as a control. RNA-seq analysis was performed on peripheral blood mononuclear cells (PBMCs). Genes with a fold-change (FC) >= 1.5 (in either direction) and false discovery rate (FDR)
Databáze: OpenAIRE
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