Genome wide studies of mRNA synthesis and degradation in eukaryotes
| Autor: | Pérez-Ortín, José E., Miguel Jiménez, María Dolores De, Chávez de Diego, Sebastián |
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| Přispěvatelé: | Universidad de Sevilla. Departamento de Genética, Universidad de Sevilla. BIO271: Expresion Genica en Eucariontes |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | idUS. Depósito de Investigación de la Universidad de Sevilla instname |
| Popis: | In recent years, the use of genome-wide technologies has revolutionized the study of eukaryotic transcription producing results for thousands of genes at every step of mRNA life. The statistical analyses of the results for a single condition, different conditions, different transcription stages, or even between different techniques, is outlining a totally new landscape of the eukaryotic transcription process. Although most studies have been conducted in the yeast Saccharomyces cerevisiae as a model cell, others have also focused on higher eukaryotes, which can also be comparatively analyzed. The picture which emerges is that transcription is a more variable process than initially suspected, with large differences between genes at each stage of the process, from initiation to mRNA degradation, but with striking similarities for functionally related genes, indicating that all steps are coordinately regulated. This article is part of a Special Issue entitled: Nuclear Transport and RNA Processing. Junta de Andalucía BIO-271 Generalitat Valenciana PROMETEO 2011/088 Unión Europea P07- CVI-02623 Unión Europea P08-CVI-03508 |
| Databáze: | OpenAIRE |
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