Anti-Pseudomonas aeruginosa IgG antibodies and chronic airway infection in bronchiectasis
| Autor: | Suarez-Cuartin G., Smith A., Abo-Leyah H., Rodrigo-Troyano A., Perea L., Vidal S., Plaza V., Fardon T.C., Sibila O., Chalmers J.D. |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Cystic Fibrosis bronchiectasis respiratory tract infection Vital Capacity sputum analysis Severity of Illness Index Article Antibodies immunology bacterium antibody blood antibody Forced Expiratory Volume chronic airway infection middle aged follow up Humans Pseudomonas Infections immunoglobulin G antibody human immunoassay Prospective Studies Respiratory Tract Infections pathophysiology isolation and purification adult microbiology Sputum major clinical study United Kingdom enzyme linked immunosorbent assay aged female priority journal sensitivity and specificity disease exacerbation physiology Pseudomonas aeruginosa Disease Progression epidemiology Pseudomonas infection prospective study |
| Zdroj: | RESPIRATORY MEDICINE r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 0954-6111 |
| Popis: | Background Identification of chronic Pseudomonas aeruginosa (PA) infection is important in the management of bronchiectasis, but requires repeated sputum sampling. We hypothesized that serum anti-PA IgG antibodies could diagnose chronic PA infection at a single visit. Methods Clinically stable bronchiectasis patients were studied prospectively. Chronic PA infection was defined as 2 or more positive sputum samples at least 3 months apart and/or failure to clear PA following eradication treatment. Baseline serum anti-PA IgG was determined by a validated ELISA kit. Results A total of 408 patients were included. Sixty of them (14.7%) had chronic PA infection and had higher anti-PA IgG levels (median 6.2 vs. 1.3 units, p |
| Databáze: | OpenAIRE |
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