Procédé de préparation, contrôles de qualité et spécifications des immunosélections CD34+ : recommandations de la Société francophone de greffe de moelle et de thérapie cellulaire (SFGM-TC)
| Autor: | Calmels B, Gautier É, Alessandra Magnani, Magrin É, Mamez AC, Vaissié A, Yakoub-Agha I, Baudoux É |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | B CANCER r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Universidad de las Islas Baleares |
| ISSN: | 0007-4551 |
| Popis: | CD34+ immunomagnetic positive selection allows for CD34+ hematopoietic progenitors separation from CD3+ lymphocytes subsets, usually from an apheresis product collected from a previously mobilized donor. This T-cell depleted stem cell graft is primarily intended for rare cases (around 2% of allotransplanted patients in France) of severe, persistent, symptomatic bi- or tri-cytopenia post-allotransplantation, in order to allow for hematologic reconstitution without increasing the risk of GvHD occurrence. Although semi-manual and complex, the process is of sufficient robustness to consistently generate a cellular product with distinctive features and specifications, based on iterative in-process quality controls, that are discussed within these guidelines. |
| Databáze: | OpenAIRE |
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