HIV co-infection in HTLV-1 carriers in Spain

Autor: de Mendoza, C, Caballero, E, Aguilera, A, Benito, R, Macia, D, Garcia-Costa, J, Soriano, V, Rodriguez, C, Vera, M, del Romero, J, Marcaida, G, Ocete, MD, Molina, I, Rodriguez-Calvino, JJ, Navarro, D, Rivero, C, Vilarino, MD, Algarate, S, Gil, J, de Lejarazu, RO, Rojo, S, Eiros, JM, San Miguel, A, Manzardo, C, Mira, JM, Garcia, J, Paz, I, Poveda, E, Calderon, E, Escudero, D, Trigo, M, Diz, J, Garcia-Campello, M, Rodriguez-Iglesias, M, Hernandez-Betancor, A, Martin, AM, Ramos, JM, Gimeno, A, Gutierrez, F, Rodriguez, JC, Sanchez, V, Gomez-Hernando, C, Cilla, G, Perez-Trallero, E, Lopez-Aldeguer, J, Fernandez-Pereira, L, Niubo, J, Hernandez, M, Lopez-Lirola, AM, Gomez-Sirvent, JL, Force, L, Cifuentes, C, Raya, C, Gonzalez-Praetorius, A, Perez, JL, Penaranda, M, Hernaez-Crespo, S, Montejo, JM, Roc, L, Martinez-Sapina, A, Viciana, I, Cabezas, T, Lozano, A, Fernandez, JM, Garcia-Bermejo, I, Gaspar, G, Garcia, R, Gorgolas, M, Vegas, C, Blas, J, Miralles, P, Valeiro, M, Aldamiz, T, Margall, N, Guardia, C, do Pico, E, Polo, I, Aguinaga, A, Ezpeleta, C, Sauleda, S, Piron, M, Gonzalez, R, Barea, L, Jimenez, A, Blanco, L, Suarez, A, Rodriguez-Avial, I, Perez-Rivilla, A, Parra, P, Fernandez, M, Fernandez-Alonso, M, Reina, G, Trevino, A, Requena, S, Benitez-Gutierrez, L, Cuervas-Mons, V, Barreiro, P, Corral, O, Gomez-Gallego, F, Perez, S, Morano, L, Spanish HTLV Network
Rok vydání: 2019
Předmět:
Zdroj: VIRUS RESEARCH
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
ISSN: 0168-1702
Popis: Background: Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. In contrast, HTLV-1 is not endemic in Spain, despite hosting huge numbers of migrants from highly endemic regions. Herein, we report the rate and main features of the HIV-HTLV co-infected population in Spain. Methods: A national registry exists in Spain for HTLV since year 1989. Data from standardized case report forms and one centralized lab repository were reviewed, especially for the subset with HTLV-HIV co-infection. Results: Up to December 2018, a total of 369 individuals with HTLV-1 had been diagnosed in Spain. 64% of the population were females, and Latin American individuals accounted for 64.5%. Classical HTLV-associated illnesses were found in 12.7% (myelopathy) and 7.6% (leukemia). HIV coinfection was found in 12 (3.2%). Of those, 3 patients (25%) were female and 39 (75%) were of non Spanish origin. All but two harbored HIV-1 subtype B, being non-B variants found in the two West Africans. Exposure had been sexual in most cases, being 4 homosexual men. Seven HTLV-HIV co-infected patients had developed AIDS and two had developed myelopathy. There was no evidence for increased HTLV-1 clinical pathogenicity due to HIV coinfection. Conclusion: HIV coinfection is infrequent (< 5%) among HTLV-1 carriers in Spain. More than half of co-infected patients come from Latin America. Sexual contact is the most frequent risk behavior, being MSM one third of cases. Late diagnosis explains the high rate (9/12) of clinical manifestations in our HIV-HTLV co-infected population.
Databáze: OpenAIRE
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