Short anogenital distance is associated with testicular germ cell tumour development

Autor: Moreno-Mendoza D., Casamonti E., Riera-Escamilla A., Pietroforte S., Corona G., Ruiz-Castañe E., Krausz C.
Rok vydání: 2020
Předmět:
Male
Anal Canal
cancer risk
penis
single nucleotide polymorphism
androgen receptor
AR protein
human
Cryptorchidism
Testis
genetics
cryptorchism
Prospective Studies
pathophysiology
scrotum
Hypospadias
adult
seminoma
risk assessment
Neoplasms
Germ Cell and Embryonal
priority journal
spermatozoon count
Receptors
Androgen
non seminomatous germinoma
luteinizing hormone
Androgens
follitropin
carcinogenesis
prospective study
hormone determination
phenotype
androgen
sperm
Polymorphism
Single Nucleotide
Article
semen analysis
histology
Testicular Neoplasms
Semen
Humans
controlled study
anogenital distance
human
gonadotropin
testis tumor
spermatozoon motility
case control study
major clinical study
human tissue
sensitivity and specificity
Spain
testosterone
physiology
metabolism
neoplasm
anatomy and histology
Zdroj: Andrology
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
ISSN: 2047-2919
DOI: 10.1111/andr.12863&partnerID=40&md5=25c90298937c7508f1806767ae1004a3
Popis: Background: Testicular germ cell tumour is a multifactorial disease in which various genetic and environmental factors play a role. Testicular germ cell tumour is part of the testicular dysgenesis syndrome which includes also cryptorchidism, hypospadias, oligo/azoospermia and short anogenital distance. Objectives: The primary objective was to examine anogenital distance in testicular germ cell tumour cases and healthy fertile controls. The secondary objective was to assess the (CAG)n polymorphism of the Androgen Receptor gene in relationship with anogenital distances and testicular germ cell tumour development. Material and Methods: 156 testicular germ cell tumour patients and 110 tumour-free normozoospermic controls of Spanish origin. All subjects underwent full andrological workup (including semen and hormone analysis) and genetic analysis (Androgen Receptor (CAG)n). The main outcome measures were the anopenile distance (AGDap), the anoscrotal distance (AGDas) and AR(CAG)n. Result: We observed significantly shorter anogenital distances in the group of testicular germ cell tumour patients in respect to controls (P
Databáze: OpenAIRE
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