Clinical profile and predictors of in-hospital mortality among older patients admitted for COVID-19

Autor: Becerra-Munoz V, Nunez-Gil I, Eid C, Aguado M, Romero R, Huang J, Mulet A, Ugo F, Rametta F, Liebetrau C, Aparisi A, Fernandez-Rozas I, Viana-Llamas M, Feltes G, Pepe M, Moreno-Rondon L, Cerrato E, Raposeiras-Roubin S, Alfonso E, Carrero-Fernandez A, Buzon-Martin L, Abumayyaleh M, Gonzalez A, Ortiz A, Macaya C, Estrada V, Fernandez-Perez C, Gomez-Doblas J
Rok vydání: 2021
Zdroj: AGE AND AGEING
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
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ISSN: 0002-0729
Popis: BACKGROUND: The coronavirus disease 2019 (COVID-19) is characterized by poor outcomes and mortality, particularly in older patients. METHODS: Post-hoc analysis of the international, multicentre, "real-world" HOPE COVID-19 registry. All patients aged =65years hospitalised for COVID-19 were selected. Epidemiological, clinical, analytical and outcome data were obtained. A comparative study between two age subgroups, 65-74 and =75years, was performed. The primary endpoint was all cause in-hospital mortality. RESULTS: 1,520 patients aged =65years (60.3% male, median age of 76 [IQR 71-83] years) were included. Comorbidities such as hypertension (69.2%), dyslipidemia (48.6%), cardiovascular diseases (any chronic heart disease in 38.4% and cerebrovascular disease in 12.5%), and chronic lung disease (25.3%) were prevalent, and 49.6% were on ACEI/ARBs. Patients aged 75years and older suffered more in-hospital complications (respiratory failure, heart failure, renal failure, sepsis) and a significantly higher mortality (18.4 vs. 48.2%, P < 0.001), but fewer admissions to intensive care units (11.2 vs. 4.8%). In the overall cohort, multivariable analysis demonstrated age =75 (OR 3.54), chronic kidney disease (OR 3.36), dementia (OR 8,06), peripheral oxygen saturation at admission 1 (OR 8.31) to be independent predictors of mortality. CONCLUSION: Patients aged =65years hospitalised for COVID-19 had high rates of in-hospital complications and mortality, especially among patients 75years or older. Age =75years, dementia, peripheral oxygen saturation 1 were independent predictors of mortality in this population.
Databáze: OpenAIRE
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