Corpus callosum size by neurosonography in fetuses with congenital heart defect and relationship with expected brain oxygen supply patterns

Autor: Pérez-Cruz M, Gómez-Domínguez O, Gibert M, Masoller-Casas N, Marimon-Garcia E, Lip-Sosa D, Bennassar M, Bonet-Carne E, Gómez-Roig MD, Martínez-Crespo JM, Gratacós E, Eixarch E
Rok vydání: 2021
Předmět:
Zdroj: ULTRASOUND IN OBSTETRICS & GYNECOLOGY
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
ISSN: 0960-7692
Popis: INTRODUCTION: This study aimed to evaluate corpus callosum (CC) size by neurosonography (NSG) in fetuses with isolated major congenital heart defect (CHD) and explore the association with the type of CHD according to the main expected brain oxygen supply patterns. METHODS: A total of 56 fetuses with CHD and 56 controls were included. Fetuses with CHD were stratified into two different categories according to the main expected pattern of cerebral arterial oxygen supply: class A, severe reduction in oxygenated brain blood supply (left outflow tract obstruction and transposition of great vessels) and class B, near normal or mildly impaired oxygenated brain blood supply (other CHD). Transvaginal NSG was performed at 32-36 weeks in all fetuses to evaluate CC length, and total area and subareas in the midsagittal plane. RESULTS: Overall, CHD fetuses showed a significantly smaller CC area as compared to controls, especially affecting the most posterior part of the CC. These changes were more prominent in class A CHD fetuses with a linear trend across the three clinical groups (Controls: 9.01 mm(2) vs. CHD class B: 8.18 mm(2) vs. CHD class A: 7.53 mm(2) , p
Databáze: OpenAIRE
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