Therapeutic strategies targeting FOXO transcription factors
| Autor: | Calissi, Giampaolo, Lam, Eric W. F., Link, Wolfgang |
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| Přispěvatelé: | Ministerio de Ciencia e Innovación (España), European Commission, CRUK Cambridge Centre, Breast Cancer Research Foundation |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | FOXO proteins are transcription factors that are involved in numerous physiological processes and in various pathological conditions, including cardiovascular disease, cancer, diabetes and chronic neurological diseases. For example, FOXO proteins are context-dependent tumour suppressors that are frequently inactivated in human cancers, and FOXO3 is the second most replicated gene associated with extreme human longevity. Therefore, pharmacological manipulation of FOXO proteins is a promising approach to developing therapeutics for cancer and for healthy ageing. In this Review, we overview the role of FOXO proteins in health and disease and discuss the pharmacological approaches to modulate FOXO function. This work was supported by the Spanish Ministry of Science, Innovation and Universities through Grant RTI2018-094629-B-I00 and by the European commission (INTERREG VA POCTEP-055 ALGARED_PLUS_5E) to W.L. E.W.-F.L.’s work is supported by MRC (MR/N012097/1), CRUK (C37/A12011) and Breast Cancer Now (2012MayPR070; 2012NovPhD016; 2014NovPhD326). |
| Databáze: | OpenAIRE |
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