IFN gamma Regulates Activated V delta 2+T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells

Autor:	Fechter, K, Dorronsoro, A, Jakobsson, E, Ferrin, I, Lang, V, Sepulveda, P, Pennington, DJ, Trigueros, C
Rok vydání:	2017
Předmět:	DELTA T-CELLS LYMPHOCYTE-PROLIFERATION INTERFERON-GAMMA STROMAL CELLS ENCEPHALOMYELITIS CYTOTOXICITY DENDRITIC CELLS INDOLEAMINE 2 3-DIOXYGENASE CYTOKINE ANALYSIS RESPONSES
Zdroj:	Plos One r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname
ISSN:	1932-6203
Popis:	gamma delta T cells play a role in a wide range of diseases such as autoimmunity and cancer. The majority of circulating human gamma delta T lymphocytes express a V gamma 9V delta 2+ (V delta 2+) T cell receptor (TCR) and following activation release pro-inflammatory cytokines. In this study, we show that IFN gamma, produced by V delta 2+ cells, activates mesenchymal stem cell (MSC)-mediated immunosupression, which in turn exerts a negative feedback mechanism on gamma delta T cell function ranging from cytokine production to proliferation. Importantly, this modulatory effect is limited to a short period of time (
Databáze:	OpenAIRE
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