Incidence and Predictors of Early Death in Patients Undergoing Percutaneous Left Atrial Appendage Closure
| Autor: | Mesnier, J, Cruz-Gonzalez, I, Arzamendi, D, Freixa, X, Nombela-Franco, L, Peral, V, Caneiro-Queija, B, Mangieri, A, Trejo-Velasco, B, Asmarats, L, Regueiro, A, McInerney, A, Mas-Llado, C, Estevez-Loureiro, R, Laricchia, A, O'Hara, G, Rodes-Cabau, J |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | JACC-Clinical Electrophysiology r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 2405-500X |
| Popis: | BACKGROUND Left atrial appendage closure (LAAC) aims to prevent ischemic events in patients with atrial fibrillation. As a preventive procedure, early death after LAAC could render the procedure futile. OBJECTIVES The authors sought to evaluate the incidence and factors associated with early death in LAAC recipients. METHODS This was a multicenter study including consecutive patients undergoing LAAC in a 10-year period (2009-2019). Death was considered early when occurring in the first year after LAAC. RESULTS A total of 807 patients (mean age 76 +/- 18 years, mean CHA(2)DS(2)-VASc score 4.5 +/- 11.5) were included. Early death occurred in 125 patients (15.5%). In the multivariable analysis, factors associated with early death after LAAC were older age HR: 1.03; 95% CI: 1.01-1.06 per year; P = 0.01), tower body mass index (HR: 0.92; 95% CI: 0.88-0.97 per 1 kg/m(2) increase; P < 0.001), diabetes (HR: 1.71; 95% CI: 1.19-2.47; P = 0.002), prior heart failure (HR: 1.74; 95% CI: 1.20-2.53; P = 0.001), and lower estimated glomerular filtration rate (HR: 1.09; 95% CI: 1.05-1.13 per 5 ml/min/1.73 m(2) decrease; P < 0.001). There was a stepwise increase in risk of early death within the first year of LAAC with the combination of different risk factors (up to 48.9% in the presence of >3 risk factors). CONCLUSIONS In this multicenter international registry, close to 1 in 6 patients died within the first year of LAAC. Older age, tow body mass index, impaired estimated glomerular filtration rate, prior diabetes, and prior heart failure are independently associated with an increased risk. The risk of early death appeared to be prohibitive (similar to 50%) in the presence of >3 of these risk factors. |
| Databáze: | OpenAIRE |
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