Metabolic Syndrome and Cardiovascular Risk in People Treated with Long-Acting Injectable Antipsychotics

Autor: Sanchez-Martinez V, Romero-Rubio D, Jose Abad-Perez M, Amparo Descalzo-Cabades M, Alonso-Gutierrez S, Salazar-Fraile J, Montagud V, Facila L
Rok vydání: 2018
Zdroj: ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
r-FIHGUV. Repositorio Institucional de Producción Científica de la Fundación de Investigación del Hospital General de Valencia
instname
ISSN: 1871-5303
Popis: Background: People with schizophrenia and other severe mental disorders have an increased mortality mainly attributed to natural causes, specifically cardiovascular disease and cancer. The metabolic syndrome and the Framingham Risk Score are epidemiologic tools related to long-term cardiovascular disease risk and they are increased in people with severe mental disorders. This increase has been attributed both to the disorder itself and to the use of antipsychotic drugs. Objective: To quantify the cardiovascular risk in a group of people treated with long-acting injectable antipsychotics. Methods: This is a cross-sectional study developed in an outpatient mental health clime in which the prevalence of metabolic syndrome was estimated and the cardiovascular risk was measured using the Framingham Risk Score. All the analyses were separated by gender. Results: 130 people (81 men) were recruited. According to the International Diabetes Federation criteria, 60 participants (46,2%) had metabolic syndrome. The individual criterion most often met in both genders was obesity. The mean Framingham Risk Score for the sample was moderate, 7,7 (SD: 6,3). For women, the risk was lower (mean 5,7, SD: 4,9) than for men (mean=9, SD: 6,7). There were no significant differences in the prevalence of metabolic syndrome and Framingham Risk Scores by long-acting injectable antipsychotic or years of treatment. Conclusion: The prevalence of metabolic syndrome and the cardiovascular risk are high in people with psychosis treated with long acting injectable antipsychotics. To better address this vulnerability, the recommendations involve both behavioral and pharmacological interventions.
Databáze: OpenAIRE
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