Resumen de tesis. Functional analysis of mammalian gametogenesis

Autor:	Gómez Hernández, Laura
Přispěvatelé:	Martín Pendás, Alberto, Llano Cuadra, María Elena
Rok vydání:	2019
Předmět:	Resumen de tesis Reproductive Medicine medicina reproductiva Thesis Abstracts Biología reproductiva 2411.16 Fisiología de la Reproducción Universidad de Salamanca (España) Esterilidad Tesis y disertaciones académicas
Zdroj:	GREDOS: Repositorio Institucional de la Universidad de Salamanca Universidad de Salamanca (USAL)
Popis:	Tesis por compendio de publicaciones [EN]Gametogenesis is among the most complex and strictly regulated differentiation programme in which a diploid cell give rise to gametes making use of a unique reductional division. Our studies focuses on different macro molecular structures that operates during meiosis, such as the cohesin complex (STAG3), the synaptonemal complex (SIX6OS1), and the spermatoproteasome (PSMA8), which we have ultimately shown its essential role for mammalian fertility. Since a large fraction of human infertilities are asymptomatic and idiopathic, we and others have postulated that mutations in meiotic genes could be the molecular mechanism underlying this disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::90bd5ad179f25056682887baa2970cc5 http://hdl.handle.net/10366/143816 Zobrazit plný text záznamu