Type II interleukin-1 receptor expression is reduced in monocytes/macrophages and atherosclerotic lesions

Autor: Pou, J, Martinez-Gonzalez, J, Rebollo, A, Rodriguez, C, Rodriguez-Calvo, R, Martin-Fuentes, P, Cenarro, A, Civeira, F, Laguna, JC, Alegret, M
Rok vydání: 2011
Předmět:
Zdroj: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
ISSN: 1388-1981
Popis: Type II interleukin-1 receptor (IL-1R2) is a non-signaling decoy receptor that negatively regulates the activity of interleukin-1 (IL-1), a pro-inflammatory cytokine involved in atherogenesis. In this article we assessed the relevance of IL-1R2 in atherosclerosis by studying its expression in monocytes from hyperlipidemic patients, in THP-1 macrophages exposed to lipoproteins and in human atherosclerotic lesions. Our results showed that the mRNA and protein expression of IL-1R2 was reduced in monocytes from patients with familial combined hyperlipidemia (-30%, p
Databáze: OpenAIRE
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